3KWJ

Structure of human DPP-IV with (2S,3S,11bS)-3-(3-Fluoromethyl-phenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ylamine

3KWJ の概要

• エントリーDOI: 10.2210/pdb3kwj/pdb
• 関連するPDBエントリー: 1NU6 1NU8 3KWF 3KWH
• 分子名称: Dipeptidyl peptidase 4 soluble form, 2-acetamido-2-deoxy-beta-D-glucopyranose, (2S,3S,11bS)-3-[3-(fluoromethyl)phenyl]-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine, ... (4 entities in total)
• 機能のキーワード: diabetes type ii, aminopeptidase, cell membrane, disulfide bond, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, signal-anchor, transmembrane
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 170550.99

構造登録者

Hennig, M.,Stihle, M.,Thoma, R. (登録日: 2009-12-01, 公開日: 2010-09-15, 最終更新日: 2020-09-09)

• 主引用文献: Boehringer, M.,Fischer, H.,Hennig, M.,Hunziker, D.,Huwyler, J.,Kuhn, B.,Loeffler, B.M.,Luebbers, T.,Mattei, P.,Narquizian, R.,Sebokova, E.,Sprecher, U.,Wessel, H.P.; Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors.; Bioorg.Med.Chem.Lett., 20:1106-1108, 2010; PubMed: 20031408; DOI: 10.1016/j.bmcl.2009.12.025

実験手法

X-RAY DIFFRACTION (2.8 Å)