3KW4

Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug ticlopidine

3KW4 の概要

• エントリーDOI: 10.2210/pdb3kw4/pdb
• 関連するPDBエントリー: 1PO5 1SUO 2BDM 2Q6N 3G5N 3G93
• 分子名称: Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, ticlopidine, ... (6 entities in total)
• 機能のキーワード: p450, cytochrome p450 2b4, monooxygenase, oxidoreductase, membrane protein, cyp 2b4, cyp lm2, endoplasmic reticulum, heme, iron, membrane, metal-binding, microsome
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• 細胞内の位置: Endoplasmic reticulum membrane; Peripheral membrane protein: P00178
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 57522.09

構造登録者

Gay, S.C.,Maekawa, K.,Roberts, A.G.,Hong, W.-X.,Zhang, Q.,Stout, C.D.,Halpert, J.R. (登録日: 2009-11-30, 公開日: 2010-09-15, 最終更新日: 2023-09-06)

• 主引用文献: Gay, S.C.,Roberts, A.G.,Maekawa, K.,Talakad, J.C.,Hong, W.X.,Zhang, Q.,Stout, C.D.,Halpert, J.R.; Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel.; Biochemistry, 49:8709-8720, 2010; PubMed: 20815363; DOI: 10.1021/bi100914z

実験手法

X-RAY DIFFRACTION (2.67 Å)