3KRY

Crystal structure of MMP-13 in complex with SC-78080

3KRY の概要

• エントリーDOI: 10.2210/pdb3kry/pdb
• 関連するPDBエントリー: 1HFC 966C
• 分子名称: Collagenase 3, ZINC ION, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: collagenase, collagenase-3, mmp-13, collagen degradation, disease mutation, disulfide bond, extracellular matrix, glycoprotein, hydrolase, metal-binding, metalloprotease, protease, secreted
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted, extracellular space, extracellular matrix : P45452
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 76952.67

構造登録者

Kiefer, J.R.,Williams, J.M.,Becker, D.P. (登録日: 2009-11-19, 公開日: 2010-10-06, 最終更新日: 2024-02-21)

• 主引用文献: Becker, D.P.,Barta, T.E.,Bedell, L.J.,Boehm, T.L.,Bond, B.R.,Carroll, J.,Carron, C.P.,Decrescenzo, G.A.,Easton, A.M.,Freskos, J.N.,Funckes-Shippy, C.L.,Heron, M.,Hockerman, S.,Howard, C.P.,Kiefer, J.R.,Li, M.H.,Mathis, K.J.,McDonald, J.J.,Mehta, P.P.,Munie, G.E.,Sunyer, T.,Swearingen, C.A.,Villamil, C.I.,Welsch, D.,Williams, J.M.,Yu, Y.,Yao, J.; Orally-active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease; J.Med.Chem., 53:6653-6680, 2010; PubMed: 20726512; DOI: 10.1021/jm100669j

実験手法

X-RAY DIFFRACTION (1.9 Å)