3KRB

Structure of Aldose Reductase from Giardia Lamblia at 1.75A Resolution

3KRB の概要

• エントリーDOI: 10.2210/pdb3krb/pdb
• 分子名称: Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, UNKNOWN ATOM OR ION, ... (5 entities in total)
• 機能のキーワード: ssgcid, sbri, emerald biostructures, university of washington, nih, niaid, aldose reductase, giardia lamblia, oxidoreductase, structural genomics, seattle structural genomics center for infectious disease
• 由来する生物種: Giardia lamblia
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 77209.27

構造登録者

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2009-11-18, 公開日: 2009-12-01, 最終更新日: 2023-09-06)

主引用文献

Ferrell, M.,Abendroth, J.,Zhang, Y.,Sankaran, B.,Edwards, T.E.,Staker, B.L.,Van Voorhis, W.C.,Stewart, L.J.,Myler, P.J.
Structure of aldose reductase from Giardia lamblia.
Acta Crystallogr.,Sect.F, 67:1113-1117, 2011

PubMed Abstract: Giardia lamblia is an anaerobic aerotolerant eukaryotic parasite of the intestines. It is believed to have diverged early from eukarya during evolution and is thus lacking in many of the typical eukaryotic organelles and biochemical pathways. Most conspicuously, mitochondria and the associated machinery of oxidative phosphorylation are absent; instead, energy is derived from substrate-level phosphorylation. Here, the 1.75 Å resolution crystal structure of G. lamblia aldose reductase heterologously expressed in Escherichia coli is reported. As in other oxidoreductases, G. lamblia aldose reductase adopts a TIM-barrel conformation with the NADP(+)-binding site located within the eight β-strands of the interior.

PubMed: 21904059
DOI: 10.1107/S1744309111030879

実験手法

X-RAY DIFFRACTION (1.75 Å)