3KR7

Human tankyrase 2 - catalytic PARP domain

Summary for 3KR7

• Entry DOI: 10.2210/pdb3kr7/pdb
• Related: 3KR8
• Descriptor: Tankyrase-2, ZINC ION, SULFATE ION, ... (5 entities in total)
• Functional Keywords: catalytic fragment, parp, structural genomics, structural genomics consortium, sgc, adp-ribosylation, ank repeat, chromosomal protein, glycosyltransferase, golgi apparatus, membrane, mrna transport, nad, nuclear pore complex, nucleus, phosphorylation, protein transport, telomere, transferase, translocation, transport, wnt-signalling
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q9H2K2
• Total number of polymer chains: 1
• Total formula weight: 27741.49

Authors

Karlberg, T.,Schutz, P.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Kallas, A.,Kotenyova, T.,Kotzsch, A.,Kraulis, P.,Nielsen, T.K.,Moche, M.,Nordlund, P.,Nyman, T.,Persson, C.,Siponen, M.I.,Thorsell, A.G.,Tresaugues, L.,Van Den Berg, S.,Weigelt, J.,Welin, M.,Wisniewska, M.,Schuler, H.,Structural Genomics Consortium (SGC) (deposition date: 2009-11-18, release date: 2009-12-15, Last modification date: 2023-11-01)

• Primary citation: Karlberg, T.,Markova, N.,Johansson, I.,Hammarstrom, M.,Schutz, P.,Weigelt, J.,Schuler, H.; Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor.; J.Med.Chem., 53:5352-5355, 2010; PubMed: 20565110; DOI: 10.1021/jm100249w

Experimental method

X-RAY DIFFRACTION (1.95 Å)