3KQB
Factor xa in complex with the inhibitor n-(3-fluoro-2'- (methylsulfonyl)biphenyl-4-yl)-1-(3-(5-oxo-4,5-dihydro-1h- 1,2,4-triazol-3-yl)phenyl)-3-(trifluoromethyl)-1h- pyrazole-5-carboxamide
Summary for 3KQB
Entry DOI | 10.2210/pdb3kqb/pdb |
Related | 3KQC 3KQD 3KQE |
Descriptor | factor Xa heavy chain, factor Xa light chain, N-(3-FLUORO-2'-(METHYLSULFONYL)BIPHENYL-4-YL)-1-(3-(5-OXO-4,5-DIHYDRO-1H-1,2,4-TRIAZOL-3-YL)PHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-5-CARBOXAMIDE, ... (5 entities in total) |
Functional Keywords | glycoprotein, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium- binding, blood coagulation, calcium, protease, secreted, egf-like domain, gamma-carboxyglutamic acid, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 32668.84 |
Authors | Sheriff, S. (deposition date: 2009-11-17, release date: 2010-02-23, Last modification date: 2023-09-06) |
Primary citation | Quan, M.L.,Pinto, D.J.,Rossi, K.A.,Sheriff, S.,Alexander, R.S.,Amparo, E.,Kish, K.,Knabb, R.M.,Luettgen, J.M.,Morin, P.,Smallwood, A.,Woerner, F.J.,Wexler, R.R. Phenyltriazolinones as potent factor Xa inhibitors. Bioorg.Med.Chem.Lett., 20:1373-1377, 2010 Cited by PubMed: 20100660DOI: 10.1016/j.bmcl.2010.01.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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