3KQA
MurA dead-end complex with terreic acid
Summary for 3KQA
Entry DOI | 10.2210/pdb3kqa/pdb |
Related | 3KQJ 3KR6 |
Descriptor | UDP-N-acetylglucosamine 1-carboxyvinyltransferase, (5S)-2,5-dihydroxy-3-methylcyclohex-2-ene-1,4-dione, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | open enzyme state, inside-out alpha/beta barrel, cell cycle, cell division, cell shape, cell wall biogenesis/degradation, peptidoglycan synthesis, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Enterobacter cloacae |
Cellular location | Cytoplasm (Probable): P33038 |
Total number of polymer chains | 4 |
Total formula weight | 180342.95 |
Authors | Schonbrunn, E. (deposition date: 2009-11-17, release date: 2010-04-28, Last modification date: 2024-10-16) |
Primary citation | Han, H.,Yang, Y.,Olesen, S.H.,Becker, A.,Betzi, S.,Schonbrunn, E. The fungal product terreic acid is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA) . Biochemistry, 49:4276-4282, 2010 Cited by PubMed: 20392080DOI: 10.1021/bi100365b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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