3KQA

MurA dead-end complex with terreic acid

Summary for 3KQA

Entry DOI	10.2210/pdb3kqa/pdb
Related	3KQJ 3KR6
Descriptor	UDP-N-acetylglucosamine 1-carboxyvinyltransferase, (5S)-2,5-dihydroxy-3-methylcyclohex-2-ene-1,4-dione, CALCIUM ION, ... (4 entities in total)
Functional Keywords	open enzyme state, inside-out alpha/beta barrel, cell cycle, cell division, cell shape, cell wall biogenesis/degradation, peptidoglycan synthesis, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Enterobacter cloacae
Cellular location	Cytoplasm (Probable): P33038
Total number of polymer chains	4
Total formula weight	180342.95
Authors	Schonbrunn, E. (deposition date: 2009-11-17, release date: 2010-04-28, Last modification date: 2023-09-06)
Primary citation	Han, H.,Yang, Y.,Olesen, S.H.,Becker, A.,Betzi, S.,Schonbrunn, E. The fungal product terreic acid is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA) . Biochemistry, 49:4276-4282, 2010 Cited by PubMed: 20392080 DOI: 10.1021/bi100365b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation