Structure of Intrinsic Factor-Cobalamin bound to its receptor Cubilin

Summary for 3KQ4

DescriptorGastric intrinsic factor, Cubilin, N-ACETYL-D-GLUCOSAMINE, ... (7 entities in total)
Functional Keywordsprotein-protein complex, cobalt, cobalt transport, disease mutation, disulfide bond, glycoprotein, secreted, transport, cholesterol metabolism, cobalamin, egf-like domain, endocytosis, endosome, lipid metabolism, lysosome, membrane, protein transport, receptor, steroid metabolism, transport protein
Biological sourceHomo sapiens (human)
Cellular locationSecreted P27352
Apical cell membrane ; Peripheral membrane protein  O60494
Total number of polymer chains6
Total molecular weight299676.48
Andersen, C.B.F.,Madsen, M.,Moestrup, S.K.,Andersen, G.R. (deposition date: 2009-11-17, release date: 2010-03-09, Last modification date: 2018-03-07)
Primary citation
Andersen, C.B.,Madsen, M.,Storm, T.,Moestrup, S.K.,Andersen, G.R.
Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes.
Nature, 464:445-448, 2010
PubMed: 20237569 (PDB entries with the same primary citation)
DOI: 10.1038/nature08874
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.242364.4%17.0%3.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution