3KQ4

Structure of Intrinsic Factor-Cobalamin bound to its receptor Cubilin

3KQ4 の概要

• エントリーDOI: 10.2210/pdb3kq4/pdb
• 関連するPDBエントリー: 2PMW
• 分子名称: Gastric intrinsic factor, Cubilin, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: protein-protein complex, cobalt, cobalt transport, disease mutation, disulfide bond, glycoprotein, secreted, transport, cholesterol metabolism, cobalamin, egf-like domain, endocytosis, endosome, lipid metabolism, lysosome, membrane, protein transport, receptor, steroid metabolism, transport protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 299190.07

構造登録者

Andersen, C.B.F.,Madsen, M.,Moestrup, S.K.,Andersen, G.R. (登録日: 2009-11-17, 公開日: 2010-03-09, 最終更新日: 2020-07-29)

• 主引用文献: Andersen, C.B.,Madsen, M.,Storm, T.,Moestrup, S.K.,Andersen, G.R.; Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes.; Nature, 464:445-448, 2010; PubMed: 20237569; DOI: 10.1038/nature08874

実験手法

X-RAY DIFFRACTION (3.3 Å)