3KOV

Structure of MEF2A bound to DNA reveals a completely folded MADS-box/MEF2 domain that recognizes DNA and recruits transcription co-factors

Summary for 3KOV

• Entry DOI: 10.2210/pdb3kov/pdb
• Descriptor: Myocyte-specific enhancer factor 2A, DNA (5'-D(*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3') (3 entities in total)
• Functional Keywords: mads-box/mef2 domain, transcription co-factors, protein-dna complex, protein-protein docking, acetylation, activator, alternative splicing, apoptosis, developmental protein, differentiation, disease mutation, dna-binding, isopeptide bond, neurogenesis, nucleus, phosphoprotein, transcription, transcription regulation, ubl conjugation, transcription-dna complex, transcription/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : Q02078
• Total number of polymer chains: 8
• Total formula weight: 58389.76

Authors

Wu, Y.,Dey, R.,Han, A.,Jayathilaka, N.,Philips, M.,Ye, J.,Chen, L. (deposition date: 2009-11-14, release date: 2010-02-16, Last modification date: 2024-02-21)

• Primary citation: Wu, Y.,Dey, R.,Han, A.,Jayathilaka, N.,Philips, M.,Ye, J.,Chen, L.; Structure of the MADS-box/MEF2 Domain of MEF2A Bound to DNA and Its Implication for Myocardin Recruitment.; J.Mol.Biol., 397:520-533, 2010; PubMed: 20132824; DOI: 10.1016/j.jmb.2010.01.067

Experimental method

X-RAY DIFFRACTION (2.9 Å)