3KOV

Structure of MEF2A bound to DNA reveals a completely folded MADS-box/MEF2 domain that recognizes DNA and recruits transcription co-factors

3KOV の概要

• エントリーDOI: 10.2210/pdb3kov/pdb
• 分子名称: Myocyte-specific enhancer factor 2A, DNA (5'-D(*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3') (3 entities in total)
• 機能のキーワード: mads-box/mef2 domain, transcription co-factors, protein-dna complex, protein-protein docking, acetylation, activator, alternative splicing, apoptosis, developmental protein, differentiation, disease mutation, dna-binding, isopeptide bond, neurogenesis, nucleus, phosphoprotein, transcription, transcription regulation, ubl conjugation, transcription-dna complex, transcription/dna
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : Q02078
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 58389.76

構造登録者

Wu, Y.,Dey, R.,Han, A.,Jayathilaka, N.,Philips, M.,Ye, J.,Chen, L. (登録日: 2009-11-14, 公開日: 2010-02-16, 最終更新日: 2024-02-21)

• 主引用文献: Wu, Y.,Dey, R.,Han, A.,Jayathilaka, N.,Philips, M.,Ye, J.,Chen, L.; Structure of the MADS-box/MEF2 Domain of MEF2A Bound to DNA and Its Implication for Myocardin Recruitment.; J.Mol.Biol., 397:520-533, 2010; PubMed: 20132824; DOI: 10.1016/j.jmb.2010.01.067

実験手法

X-RAY DIFFRACTION (2.9 Å)