3KOA

M296I mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA and GTP

Summary for 3KOA

• Entry DOI: 10.2210/pdb3koa/pdb
• Related: 1U09 1WNE 2D7S 2E9T 2E9Z 2F8E 3KLV 3KMQ 3KMS 3KNA
• Descriptor: 3D polymerase, RNA (5'-R(P*AP*UP*GP*GP*GP*C)-3'), RNA (5'-R(P*CP*CP*CP*G)-3'), ... (6 entities in total)
• Functional Keywords: rna dependent rna polymerase, ribavirin, 3d polymerase, foot-and-mouth disease virus, transferase-rna complex, transferase/rna
• Biological source: Foot-and-mouth disease virus - type C
• Total number of polymer chains: 3
• Total formula weight: 56838.21

Authors

Ferrer-Orta, C.,Verdaguer, N.,Perez-Luque, R. (deposition date: 2009-11-13, release date: 2010-07-07, Last modification date: 2023-11-01)

• Primary citation: Ferrer-Orta, C.,Sierra, M.,Agudo, R.,de la Higuera, I.,Arias, A.,Perez-Luque, R.,Escarmis, C.,Domingo, E.,Verdaguer, N.; Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin; J.Virol., 84:6188-6199, 2010; PubMed: 20392853; DOI: 10.1128/JVI.02420-09

Experimental method

X-RAY DIFFRACTION (2.4 Å)