3KO0

Structure of the tfp-ca2+-bound activated form of the s100a4 Metastasis factor

3KO0 の概要

• エントリーDOI: 10.2210/pdb3ko0/pdb
• 分子名称: Protein S100-A4, 10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: mts1, s100a4, tfp, ca2+, oligomerization, acetylation, calcium, metal binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 20
• 化学式量合計: 252813.72

構造登録者

Malashkevich, V.N.,Dulyaninova, N.G.,Knight, D.,Almo, S.C.,Bresnick, A.R. (登録日: 2009-11-12, 公開日: 2010-05-26, 最終更新日: 2024-02-21)

• 主引用文献: Malashkevich, V.N.,Dulyaninova, N.G.,Ramagopal, U.A.,Liriano, M.A.,Varney, K.M.,Knight, D.,Brenowitz, M.,Weber, D.J.,Almo, S.C.,Bresnick, A.R.; Phenothiazines inhibit S100A4 function by inducing protein oligomerization.; Proc.Natl.Acad.Sci.USA, 107:8605-8610, 2010; PubMed: 20421509; DOI: 10.1073/pnas.0913660107

実験手法

X-RAY DIFFRACTION (2.3 Å)