3KMR
Crystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment
Summary for 3KMR
Entry DOI | 10.2210/pdb3kmr/pdb |
Descriptor | Retinoic acid receptor alpha, Nuclear receptor coactivator 1, 4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid, ... (4 entities in total) |
Functional Keywords | nuclear receptor transcription factor ligand binding domain, dna-binding, metal-binding, nucleus, phosphoprotein, proto-oncogene, receptor, transcription, transcription regulation, zinc-finger, activator, acyltransferase, isopeptide bond, transferase |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P10276 Nucleus (By similarity): Q15788 |
Total number of polymer chains | 2 |
Total formula weight | 31910.91 |
Authors | Bourguet, W.,Teyssier, C. (deposition date: 2009-11-11, release date: 2010-06-02, Last modification date: 2023-09-06) |
Primary citation | le Maire, A.,Teyssier, C.,Erb, C.,Grimaldi, M.,Alvarez, S.,de Lera, A.R.,Balaguer, P.,Gronemeyer, H.,Royer, C.A.,Germain, P.,Bourguet, W. A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor. Nat.Struct.Mol.Biol., 17:801-807, 2010 Cited by PubMed: 20543827DOI: 10.1038/nsmb.1855 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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