3KLE
Crystal structure of AZT-resistant HIV-1 Reverse Transcriptase crosslinked to a DSDNA with a bound excision product, AZTPPPPA
3KLE の概要
エントリーDOI | 10.2210/pdb3kle/pdb |
関連するPDBエントリー | 3KLF 3KLG 3KLH 3KLI |
関連するBIRD辞書のPRD_ID | PRD_900032 |
分子名称 | Reverse transcriptase/ribonuclease H, p51 RT, DNA (25-MER), ... (9 entities in total) |
機能のキーワード | azt resistance mechanism, hiv-1, reverse transcriptase, rt, azt, resistance mutations, p51/p66, nucleoside inhibitor, nucleotide excision, thymidine analog mutations, aids, hiv, dna polymerase, nrti, nrti resistance, aztppppa, aztp4a, azt adenosine dinucleoside tetraphosphate, dna-directed dna polymerase, endonuclease, hydrolase, magnesium, metal-binding, multifunctional enzyme, myristate, nuclease, rna-directed dna polymerase, transferase, transferase-dna complex, transferase/dna |
由来する生物種 | Human immunodeficiency virus type 1 (HIV-1) 詳細 |
細胞内の位置 | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366 |
タンパク質・核酸の鎖数 | 16 |
化学式量合計 | 526900.62 |
構造登録者 | |
主引用文献 | Tu, X.,Das, K.,Han, Q.,Bauman, J.D.,Clark, A.D.,Hou, X.,Frenkel, Y.V.,Gaffney, B.L.,Jones, R.A.,Boyer, P.L.,Hughes, S.H.,Sarafianos, S.G.,Arnold, E. Structural basis of HIV-1 resistance to AZT by excision. Nat.Struct.Mol.Biol., 17:1202-1209, 2010 Cited by PubMed: 20852643DOI: 10.1038/nsmb.1908 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.2 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード