3KLE

Crystal structure of AZT-resistant HIV-1 Reverse Transcriptase crosslinked to a DSDNA with a bound excision product, AZTPPPPA

3KLE の概要

• エントリーDOI: 10.2210/pdb3kle/pdb
• 関連するPDBエントリー: 3KLF 3KLG 3KLH 3KLI
• 関連するBIRD辞書のPRD_ID: PRD_900032
• 分子名称: Reverse transcriptase/ribonuclease H, p51 RT, DNA (25-MER), ... (9 entities in total)
• 機能のキーワード: azt resistance mechanism, hiv-1, reverse transcriptase, rt, azt, resistance mutations, p51/p66, nucleoside inhibitor, nucleotide excision, thymidine analog mutations, aids, hiv, dna polymerase, nrti, nrti resistance, aztppppa, aztp4a, azt adenosine dinucleoside tetraphosphate, dna-directed dna polymerase, endonuclease, hydrolase, magnesium, metal-binding, multifunctional enzyme, myristate, nuclease, rna-directed dna polymerase, transferase, transferase-dna complex, transferase/dna
• 由来する生物種: Human immunodeficiency virus type 1 (HIV-1); 詳細
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366
• タンパク質・核酸の鎖数: 16
• 化学式量合計: 526900.62

構造登録者

Tu, X.,Das, K.,Sarafianos, S.G.,Arnold, E. (登録日: 2009-11-07, 公開日: 2010-09-22, 最終更新日: 2021-10-13)

• 主引用文献: Tu, X.,Das, K.,Han, Q.,Bauman, J.D.,Clark, A.D.,Hou, X.,Frenkel, Y.V.,Gaffney, B.L.,Jones, R.A.,Boyer, P.L.,Hughes, S.H.,Sarafianos, S.G.,Arnold, E.; Structural basis of HIV-1 resistance to AZT by excision.; Nat.Struct.Mol.Biol., 17:1202-1209, 2010; PubMed: 20852643; DOI: 10.1038/nsmb.1908

実験手法

X-RAY DIFFRACTION (3.2 Å)