3KLA
Ca2+ release from the endoplasmic reticulum of NY-ESO-1 specific T cells is modulated by the affinity of T cell receptor and by the use of the CD8 co-receptor
Summary for 3KLA
Entry DOI | 10.2210/pdb3kla/pdb |
Descriptor | HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, NYESO-1 peptide analogue, ... (4 entities in total) |
Functional Keywords | mhc, tumour, immunology, disulfide bond, glycoprotein, immune response, membrane, mhc i, transmembrane, immunoglobulin domain, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P01892 Secreted: P61769 Cytoplasm: P78358 |
Total number of polymer chains | 6 |
Total formula weight | 89675.84 |
Authors | Chen, J.L.,Morgan, A.J.,Stewart-Jones, G.,Shepherd, D.,Bossi, G.,Wooldridge, L. (deposition date: 2009-11-07, release date: 2010-02-16, Last modification date: 2021-10-13) |
Primary citation | Chen, J.L.,Morgan, A.J.,Stewart-Jones, G.,Shepherd, D.,Bossi, G.,Wooldridge, L.,Hutchinson, S.L.,Sewell, A.K.,Griffiths, G.M.,van der Merwe, P.A.,Jones, E.Y.,Galione, A.,Cerundolo, V. Ca2+ Release from the Endoplasmic Reticulum of NY-ESO-1-Specific T Cells Is Modulated by the Affinity of TCR and by the Use of the CD8 Coreceptor. J.Immunol., 184:1829-1839, 2010 Cited by PubMed: 20053942DOI: 10.4049/jimmunol.0902103 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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