3KKT

Crystal structure of human PDE4b with 5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-yloxy]-4-methoxyp henyl]tetrahydro-2(1H)-pyrimidinone reveals ordering of the C-terminal helix residues 502-509.

3KKT の概要

• エントリーDOI: 10.2210/pdb3kkt/pdb
• 分子名称: cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, 5-{3-[(1S,2S,4R)-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl}tetrahydropyrimidin-2(1H)-one, ... (6 entities in total)
• 機能のキーワード: phosphodiesterase, alternative splicing, hydrolase, phosphoprotein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 92404.97

構造登録者

Cheng, R.K.Y.,Crawley, L.,Barker, J.,Whittaker, M. (登録日: 2009-11-06, 公開日: 2009-11-24, 最終更新日: 2023-09-06)

• 主引用文献: Cheng, R.K.Y.,Crawley, L.,Barker, J.,Whittaker, M.; Crystal structure of human PDE4b with 5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-yloxy]-4-methoxyp henyl]tetrahydro-2(1H)-pyrimidinone reveals ordering of the C-terminal helix residues 502-509.; To be Published,

実験手法

X-RAY DIFFRACTION (2.48 Å)