3KJ1

Mcl-1 in complex with Bim BH3 mutant I2dA

3KJ1 の概要

• エントリーDOI: 10.2210/pdb3kj1/pdb
• 関連するPDBエントリー: 2PQK 3KJ0 3KJ2
• 分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 11, ZINC ION, ... (6 entities in total)
• 機能のキーワード: bcl-2, bh3, apoptosis, protein-peptide complex, alternative splicing, cytoplasm, developmental protein, differentiation, isopeptide bond, membrane, mitochondrion, nucleus, phosphoprotein, polymorphism, transmembrane, ubl conjugation
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane ; Single-pass membrane protein : Q07820; Endomembrane system ; Peripheral membrane protein . Isoform BimEL: Mitochondrion. Isoform BimL: Mitochondrion. Isoform BimS: Mitochondrion. Isoform Bim-alpha1: Mitochondrion: O43521
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 21116.96

構造登録者

Fire, E.,Grant, R.A.,Keating, A.E. (登録日: 2009-11-02, 公開日: 2010-02-16, 最終更新日: 2023-12-27)

• 主引用文献: Fire, E.,Gulla, S.V.,Grant, R.A.,Keating, A.E.; Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes.; Protein Sci., 19:507-519, 2010; PubMed: 20066663; DOI: 10.1002/pro.329

実験手法

X-RAY DIFFRACTION (1.945 Å)