3KJ1
Mcl-1 in complex with Bim BH3 mutant I2dA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 158 | 17937.4 | 1 | UniProt (Q07820) Pfam (PF00452) | Homo sapiens (human) | Bcl-2-related protein EAT/mcl1, mcl1/EAT, Bcl-2-like protein 3, Bcl2-L-3 |
| 2 | B (B) | Bcl-2-like protein 11 | polymer | 22 | 2758.1 | 1 | UniProt (O43521) Pfam (PF08945) | Homo sapiens (human) | Bcl2-L-11, Bcl2-interacting mediator of cell death |
| 3 | C, D, E, F, I (A, B) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) | |||
| 4 | G (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 5 | H (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 116 | Chemie (HOH) |
Sequence modifications
A: 172 - 327 (UniProt: Q07820)
B: 1 - 21 (UniProt: O43521)
| PDB | External Database | Details |
|---|---|---|
| Gly 170 | - | expression tag |
| Ser 171 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 6 | Ile 148 | engineered mutation |
| Arg 22 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 20695.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 421.5 | |
| All* | Total formula weight | 21117.0 |
