3KHH

Dpo4 extension ternary complex with a C base opposite the 2-aminofluorene-guanine [AF]G lesion

3KHH の概要

• エントリーDOI: 10.2210/pdb3khh/pdb
• 関連するPDBエントリー: 3KHG 3KHL 3KHR
• 分子名称: DNA polymerase IV, 5'-D(*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*GP*(DOC))-3', 5'-D(*CP*CP*TP*A*AP*CP*GP*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*CP*C)-3', ... (7 entities in total)
• 機能のキーワード: lesion bypass, dna polymerase, y-family polymerase, 2-aminofluorene, semi-targeted mutagenesis, dna damage, dna repair, dna replication, dna-binding, dna-directed dna polymerase, magnesium, metal-binding, mutator protein, nucleotidyltransferase, transferase, transferase-dna complex, transferase/dna
• 由来する生物種: Sulfolobus solfataricus P2; 詳細
• 細胞内の位置: Cytoplasm (Probable): Q97W02
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 98958.75

構造登録者

Rechkoblit, O.,Malinina, L.,Patel, D.J. (登録日: 2009-10-30, 公開日: 2010-02-16, 最終更新日: 2023-09-06)

• 主引用文献: Rechkoblit, O.,Kolbanovskiy, A.,Malinina, L.,Geacintov, N.E.,Broyde, S.,Patel, D.J.; Mechanism of error-free and semitargeted mutagenic bypass of an aromatic amine lesion by Y-family polymerase Dpo4.; Nat.Struct.Mol.Biol., 17:379-388, 2010; PubMed: 20154704; DOI: 10.1038/nsmb.1771

実験手法

X-RAY DIFFRACTION (2.7 Å)