3KEK
Crystal Structure of Human MMP-13 complexed with a (pyridin-4-yl)-2H-tetrazole compound
3KEK の概要
エントリーDOI | 10.2210/pdb3kek/pdb |
関連するPDBエントリー | 3KEC 3KEJ |
分子名称 | Collagenase 3, ZINC ION, CALCIUM ION, ... (5 entities in total) |
機能のキーワード | s1' inhibitor; selective mmp-13 inhibitor; s1' specificity, no contact to zn, collagen degradation, disease mutation, disulfide bond, extracellular matrix, glycoprotein, hydrolase, metal-binding, metalloprotease, protease, secreted, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Secreted, extracellular space, extracellular matrix : P45452 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 38965.02 |
構造登録者 | |
主引用文献 | Schnute, M.E.,O'Brien, P.M.,Nahra, J.,Morris, M.,Howard Roark, W.,Hanau, C.E.,Ruminski, P.G.,Scholten, J.A.,Fletcher, T.R.,Hamper, B.C.,Carroll, J.N.,Patt, W.C.,Shieh, H.S.,Collins, B.,Pavlovsky, A.G.,Palmquist, K.E.,Aston, K.W.,Hitchcock, J.,Rogers, M.D.,McDonald, J.,Johnson, A.R.,Munie, G.E.,Wittwer, A.J.,Man, C.F.,Settle, S.L.,Nemirovskiy, O.,Vickery, L.E.,Agawal, A.,Dyer, R.D.,Sunyer, T. Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis. Bioorg.Med.Chem.Lett., 20:576-580, 2009 Cited by PubMed: 20005097DOI: 10.1016/j.bmcl.2009.11.081 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.97 Å) |
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