3KEH

Crystal Structure of N370S Glucocerebrosidase mutant at pH 7.4

3KEH の概要

• エントリーDOI: 10.2210/pdb3keh/pdb
• 関連するPDBエントリー: 3KE0
• 分子名称: Glucocerebrosidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-alpha-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: glucocerebrosidase, acid-beta-glucosidase, n370s, glucosyceremidase, tim barrel, alternative initiation, disease mutation, disulfide bond, gaucher disease, glycoprotein, glycosidase, hydrolase, ichthyosis, lipid metabolism, lysosome, membrane, sphingolipid metabolism
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 113305.11

構造登録者

Wei, R.R.,Boucher, S.,Pan, C.Q.,Edmunds, T. (登録日: 2009-10-26, 公開日: 2010-10-27, 最終更新日: 2024-04-03)

• 主引用文献: Wei, R.R.,Boucher, S.,Hughes, H.,Guziewica, N.,Vanpatten, S.,Pan, C.Q.,Edmunds, T.; Crystal Structure of Glucocerebrosidase Containing the N370S mutation: Implication on Chaperon Therapy; To be Published,

実験手法

X-RAY DIFFRACTION (2.8 Å)