3KED

Crystal structure of Aminopeptidase N in complex with 2,4-diaminobutyric acid

Summary for 3KED

• Entry DOI: 10.2210/pdb3ked/pdb
• Related: 2hpo
• Descriptor: Aminopeptidase N, ZINC ION, 2,4-DIAMINOBUTYRIC ACID, ... (7 entities in total)
• Functional Keywords: aminopeptidase, thermolysin like active site, amino switch, inhibitor, ligand design, cell inner membrane, cell membrane, hydrolase, membrane, metal-binding, metalloprotease, protease
• Biological source: Escherichia coli
• Cellular location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side: P04825
• Total number of polymer chains: 1
• Total formula weight: 102811.75

Authors

Addlagatta, A.,Gumpena, R. (deposition date: 2009-10-25, release date: 2010-11-03, Last modification date: 2023-11-01)

• Primary citation: Gumpena, R.,Kishor, C.,Ganji, R.J.,Addlagatta, A.; Discovery of alpha, beta- and alpha, gamma-Diamino Acid Scaffolds for the Inhibition of M1 Family Aminopeptidases; Chemmedchem, 6:1971-1976, 2011; PubMed: 22025387; DOI: 10.1002/cmdc.201100298

Experimental method

X-RAY DIFFRACTION (2.3 Å)