3KED

Crystal structure of Aminopeptidase N in complex with 2,4-diaminobutyric acid

3KED の概要

• エントリーDOI: 10.2210/pdb3ked/pdb
• 関連するPDBエントリー: 2hpo
• 分子名称: Aminopeptidase N, ZINC ION, 2,4-DIAMINOBUTYRIC ACID, ... (7 entities in total)
• 機能のキーワード: aminopeptidase, thermolysin like active site, amino switch, inhibitor, ligand design, cell inner membrane, cell membrane, hydrolase, membrane, metal-binding, metalloprotease, protease
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side: P04825
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 102811.75

構造登録者

Addlagatta, A.,Gumpena, R. (登録日: 2009-10-25, 公開日: 2010-11-03, 最終更新日: 2023-11-01)

• 主引用文献: Gumpena, R.,Kishor, C.,Ganji, R.J.,Addlagatta, A.; Discovery of alpha, beta- and alpha, gamma-Diamino Acid Scaffolds for the Inhibition of M1 Family Aminopeptidases; Chemmedchem, 6:1971-1976, 2011; PubMed: 22025387; DOI: 10.1002/cmdc.201100298

実験手法

X-RAY DIFFRACTION (2.3 Å)