3KAN
D-dopachrome tautomerase (D-DT)/macrophage migration inhibitory factor 2 (MIF2) complexed with inhibitor 4-IPP
Summary for 3KAN
Entry DOI | 10.2210/pdb3kan/pdb |
Related | 1DPT 3B64 3B9S 3KER |
Descriptor | D-dopachrome tautomerase, 4-phenylpyrimidine, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | immune response, cytokine, tautomerase, cytokine-inhibitor complex, cytokine/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 3 |
Total formula weight | 38320.04 |
Authors | Zierow, S.,Lolis, E. (deposition date: 2009-10-19, release date: 2011-04-20, Last modification date: 2023-09-06) |
Primary citation | Rajasekaran, D.,Zierow, S.,Syed, M.,Bucala, R.,Bhandari, V.,Lolis, E.J. Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment. Faseb J., 28:4961-4971, 2014 Cited by PubMed: 25016026DOI: 10.1096/fj.14-256636 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.13 Å) |
Structure validation
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