3K5T

Crystal structure of human diamine oxidase in space group C2221

3K5T の概要

• エントリーDOI: 10.2210/pdb3k5t/pdb
• 分子名称: Diamine oxidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COPPER (II) ION, ... (7 entities in total)
• 機能のキーワード: oxidoreductase, copper amine oxidase, cao, topaquinone, tpq, diamine oxidase, dao, human, glycoprotein, heparin-binding, metal-binding, secreted
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 84769.60

構造登録者

McGrath, A.P.,Guss, J.M. (登録日: 2009-10-08, 公開日: 2010-02-09, 最終更新日: 2023-09-06)

主引用文献

McGrath, A.P.,Hilmer, K.M.,Collyer, C.A.,Dooley, D.M.,Guss, J.M.
A new crystal form of human diamine oxidase.
Acta Crystallogr.,Sect.F, 66:137-142, 2010

PubMed Abstract: Copper amine oxidases (CAOs) are ubiquitous in nature and catalyse the oxidative deamination of primary amines to the corresponding aldehydes. Humans have three viable CAO genes (AOC1-3). AOC1 encodes human diamine oxidase (hDAO), which is the frontline enzyme for histamine metabolism. hDAO is unique among CAOs in that it has a distinct substrate preference for diamines. The structure of hDAO in space group P2(1)2(1)2(1) with two molecules in the asymmetric unit has recently been reported. Here, the structure of hDAO refined to 2.1 A resolution in space group C222(1) with one molecule in the asymmetric unit is reported.

PubMed: 20124708
DOI: 10.1107/S1744309109052130

実験手法

X-RAY DIFFRACTION (2.11 Å)