3K4V

New crystal form of HIV-1 Protease/Saquinavir structure reveals carbamylation of N-terminal proline

3K4V の概要

• エントリーDOI: 10.2210/pdb3k4v/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000454
• 分子名称: HIV-1 Protease, DIMETHYL SULFOXIDE, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, ... (6 entities in total)
• 機能のキーワード: hydrolase-hydrolase inhibitor complex, carbamylation, aids, aspartyl protease, capsid maturation, capsid protein, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 (HIV-1); 詳細
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 44706.43

構造登録者

Olajuyigbe, F.M.,Demitri, N.,Ajele, J.O.,Maurizio, E.,Randaccio, L.,Geremia, S. (登録日: 2009-10-06, 公開日: 2010-06-09, 最終更新日: 2023-09-06)

• 主引用文献: Olajuyigbe, F.M.,Demitri, N.,Ajele, J.O.,Maurizio, E.,Randaccio, L.,Geremia, S.; Carbamylation of N-terminal proline.; ACS Med Chem Lett, 1:254-257, 2010; PubMed: 24900204; DOI: 10.1021/ml100046d

実験手法

X-RAY DIFFRACTION (1.39 Å)