3K41

Crystal structure of sCD-MPR mutant E19Q/K137M bound to Man-6-P

Summary for 3K41

• Entry DOI: 10.2210/pdb3k41/pdb
• Related: 3K42 3K43
• Descriptor: Cation-dependent mannose-6-phosphate receptor, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: transport, lysosome, mannose, receptor, sugar binding, glycoprotein, membrane, phosphoprotein, transmembrane, protein transport, sugar binding protein
• Biological source: Bos taurus (bovine,cow,domestic cattle,domestic cow)
• Cellular location: Lysosome membrane ; Single-pass type I membrane protein : P11456
• Total number of polymer chains: 2
• Total formula weight: 38240.34

Authors

Olson, L.J.,Sun, G.,Bohnsack, R.N.,Peterson, F.C.,Dahms, N.M.,Kim, J.J.P. (deposition date: 2009-10-05, release date: 2009-11-24, Last modification date: 2023-09-06)

• Primary citation: Olson, L.J.,Sun, G.,Bohnsack, R.N.,Peterson, F.C.,Dahms, N.M.,Kim, J.J.; Intermonomer interactions are essential for lysosomal enzyme binding by the cation-dependent mannose 6-phosphate receptor.; Biochemistry, 49:236-246, 2010; PubMed: 19928875; DOI: 10.1021/bi901725x

Experimental method

X-RAY DIFFRACTION (1.9 Å)