3K40

Crystal structure of Drosophila 3,4-dihydroxyphenylalanine decarboxylase

3K40 の概要

• エントリーDOI: 10.2210/pdb3k40/pdb
• 分子名称: Aromatic-L-amino-acid decarboxylase, GLYCEROL (3 entities in total)
• 機能のキーワード: plp dependent protein, alpha beta protein, alternative splicing, catecholamine biosynthesis, decarboxylase, lyase, polymorphism, pyridoxal phosphate, cg10697-pb isoform b
• 由来する生物種: Drosophila melanogaster (Fruit fly)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 107831.52

構造登録者

Han, Q.,Ding, H.,Robinson, H.,Christensen, B.M.,Li, J. (登録日: 2009-10-05, 公開日: 2010-02-02, 最終更新日: 2023-11-22)

主引用文献

Han, Q.,Ding, H.,Robinson, H.,Christensen, B.M.,Li, J.
Crystal structure and substrate specificity of Drosophila 3,4-dihydroxyphenylalanine decarboxylase
Plos One, 5:e8826-e8826, 2010

PubMed Abstract: 3,4-Dihydroxyphenylalanine decarboxylase (DDC), also known as aromatic L-amino acid decarboxylase, catalyzes the decarboxylation of a number of aromatic L-amino acids. Physiologically, DDC is responsible for the production of dopamine and serotonin through the decarboxylation of 3,4-dihydroxyphenylalanine and 5-hydroxytryptophan, respectively. In insects, both dopamine and serotonin serve as classical neurotransmitters, neuromodulators, or neurohormones, and dopamine is also involved in insect cuticle formation, eggshell hardening, and immune responses.

PubMed: 20098687
DOI: 10.1371/journal.pone.0008826

実験手法

X-RAY DIFFRACTION (1.75 Å)