3K2L

Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2)

3K2L の概要

• エントリーDOI: 10.2210/pdb3k2l/pdb
• 分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 2, SULFATE ION, SODIUM ION, ... (5 entities in total)
• 機能のキーワード: dyrk2, dual-specificity tyrosine-(y)-phosphorylation regulated kinase 2, psk-h2, kinase, structural genomics consortium, sgc, apoptosis, atp-binding, magnesium, manganese, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q92630
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 50046.88

構造登録者

Filippakopoulos, P.,Myrianthopoulos, V.,Soundararajan, M.,Krojer, T.,Hapka, E.,Fedorov, O.,Berridge, G.,Wang, J.,Shrestha, L.,Pike, A.C.W.,Ugochukwu, E.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Weigelt, J.,Bountra, C.,Mikros, E.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2009-09-30, 公開日: 2009-10-13, 最終更新日: 2023-11-22)

• 主引用文献: Soundararajan, M.,Roos, A.K.,Savitsky, P.,Filippakopoulos, P.,Kettenbach, A.N.,Olsen, J.V.,Gerber, S.A.,Eswaran, J.,Knapp, S.,Elkins, J.M.; Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition.; Structure, 21:986-996, 2013; PubMed: 23665168; DOI: 10.1016/j.str.2013.03.012

実験手法

X-RAY DIFFRACTION (2.36 Å)