3K1W
New Classes of Potent and Bioavailable Human Renin Inhibitors
Summary for 3K1W
Entry DOI | 10.2210/pdb3k1w/pdb |
Descriptor | Renin, 4-{4-[3-(2-bromo-5-fluorophenoxy)propyl]phenyl}-N-(2-chlorobenzyl)-N-cyclopropyl-1,2,5,6-tetrahydropyridine-3-carboxamide, FORMIC ACID, ... (7 entities in total) |
Functional Keywords | renin, protease, alternative splicing, aspartyl protease, cleavage on pair of basic residues, disease mutation, disulfide bond, glycoprotein, hydrolase, membrane, polymorphism, secreted, zymogen |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P00797 |
Total number of polymer chains | 2 |
Total formula weight | 76576.11 |
Authors | Prade, L. (deposition date: 2009-09-29, release date: 2010-03-02, Last modification date: 2020-07-29) |
Primary citation | Remen, L.,Bezencon, O.,Richard-Bildstein, S.,Bur, D.,Prade, L.,Corminboeuf, O.,Boss, C.,Grisostomi, C.,Sifferlen, T.,Strickner, P.,Hess, P.,Delahaye, S.,Treiber, A.,Weller, T.,Binkert, C.,Steiner, B.,Fischli, W. New classes of potent and bioavailable human renin inhibitors Bioorg.Med.Chem.Lett., 19:6762-6765, 2009 Cited by PubMed: 19853442DOI: 10.1016/j.bmcl.2009.09.104 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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