Summary for 3K1V
| Entry DOI | 10.2210/pdb3k1v/pdb |
| Descriptor | PreQ1 riboswitch, 7-DEAZA-7-AMINOMETHYL-GUANINE, CALCIUM ION, ... (4 entities in total) |
| Functional Keywords | rna; aptamer; riboswitch; queuosine; preq1, rna |
| Total number of polymer chains | 1 |
| Total formula weight | 11175.01 |
| Authors | Klein, D.J.,Edwards, T.E.,Ferre-D'Amare, A.R. (deposition date: 2009-09-28, release date: 2009-10-06, Last modification date: 2024-02-21) |
| Primary citation | Klein, D.J.,Edwards, T.E.,Ferre-D'Amare, A.R. Cocrystal Structure of a Class I Preq1 Riboswitch Reveals a Pseudoknot Recognizing an Essential Hypermodified Nucleobase Nat.Struct.Mol.Biol., 16:343-, 2009 Cited by PubMed Abstract: Riboswitches are mRNA domains that bind metabolites and modulate gene expression in cis. We report cocrystal structures of a remarkably compact riboswitch (34 nucleotides suffice for ligand recognition) from Bacillus subtilis that is selective for the essential nucleobase preQ(1) (7-aminomethyl-7-deazaguanine). The structures reveal a previously unrecognized pseudoknot fold and suggest a conserved gene-regulatory mechanism whereby ligand binding promotes sequestration of an RNA segment that otherwise assembles into a transcriptional antiterminator. PubMed: 19234468DOI: 10.1038/NSMB.1563 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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