3JY9

Janus Kinase 2 Inhibitors

3JY9 の概要

• エントリーDOI: 10.2210/pdb3jy9/pdb
• 分子名称: Tyrosine-protein kinase JAK2, (3S)-3-(4-hydroxyphenyl)-1,5-dihydro-1,5,12-triazabenzo[4,5]cycloocta[1,2,3-cd]inden-4(3H)-one, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: kinase, inhibitor, jak2, janus kinase, atp-binding, disease mutation, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, transferase, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endomembrane system; Peripheral membrane protein (By similarity): O60674
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37019.03

構造登録者

Zuccola, H.J.,Ledeboer, M.W.,Pierce, A.C. (登録日: 2009-09-21, 公開日: 2009-12-01, 最終更新日: 2024-04-03)

• 主引用文献: Wang, T.,Duffy, J.P.,Wang, J.,Halas, S.,Salituro, F.G.,Pierce, A.C.,Zuccola, H.J.,Black, J.R.,Hogan, J.K.,Jepson, S.,Shlyakter, D.,Mahajan, S.,Gu, Y.,Hoock, T.,Wood, M.,Furey, B.F.,Frantz, J.D.,Dauffenbach, L.M.,Germann, U.A.,Fan, B.,Namchuk, M.,Bennani, Y.L.,Ledeboer, M.W.; Janus kinase 2 inhibitors. Synthesis and characterization of a novel polycyclic azaindole.; J.Med.Chem., 52:7938-7941, 2009; PubMed: 20014869; DOI: 10.1021/jm901383u

実験手法

X-RAY DIFFRACTION (2.1 Å)