3JXT
Crystal structure of the third PDZ domain of SAP-102 in complex with a fluorogenic peptide-based ligand
Summary for 3JXT
| Entry DOI | 10.2210/pdb3jxt/pdb |
| Descriptor | Disks large homolog 3, Voltage-dependent calcium channel gamma-2 subunit, ACETATE ION, ... (4 entities in total) |
| Functional Keywords | sap102, dlg3, stargazin, 4-dmap, 4db, pdz domain, solvatochromic flurophore, fluorogenic probe, calcium channel, calcium transport, ion transport, ionic channel, transport, voltage-gated channel, signaling protein |
| Biological source | Rattus norvegicus (rat) More |
| Cellular location | Membrane; Multi-pass membrane protein: O88602 |
| Total number of polymer chains | 4 |
| Total formula weight | 24095.75 |
| Authors | Sainlos, M.,Olivier, N.B.,Imperiali, B. (deposition date: 2009-09-21, release date: 2010-09-29, Last modification date: 2024-11-20) |
| Primary citation | Sainlos, M.,Iskenderian-Epps, W.S.,Olivier, N.B.,Choquet, D.,Imperiali, B. Caged mono- and divalent ligands for light-assisted disruption of PDZ domain-mediated interactions. J.Am.Chem.Soc., 135:4580-4583, 2013 Cited by PubMed Abstract: We report a general method for light-assisted control of interactions of PDZ domain binding motifs with their cognate domains by the incorporation of a photolabile caging group onto the essential C-terminal carboxylate binding determinant of the motif. The strategy was implemented and validated for both simple monovalent and biomimetic divalent ligands, which have recently been established as powerful tools for acute perturbation of native PDZ domain-dependent interactions in live cells. PubMed: 23480637DOI: 10.1021/ja309870q PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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