3JWE

Crystal structure of human mono-glyceride lipase in complex with SAR629

Summary for 3JWE

Entry DOI	10.2210/pdb3jwe/pdb
Descriptor	MGLL protein, 1-[bis(4-fluorophenyl)methyl]-4-(1H-1,2,4-triazol-1-ylcarbonyl)piperazine (3 entities in total)
Functional Keywords	alpha-beta hydrolase, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	71735.21
Authors	Bertrand, T.,Auge, F.,Houtmann, J.,Rak, A.,Vallee, F.,Mikol, V.,Berne, P.F.,Michot, N.,Cheuret, D.,Hoornaert, C.,Mathieu, M. (deposition date: 2009-09-18, release date: 2010-01-26, Last modification date: 2023-09-06)
Primary citation	Bertrand, T.,Auge, F.,Houtmann, J.,Rak, A.,Vallee, F.,Mikol, V.,Berne, P.F.,Michot, N.,Cheuret, D.,Hoornaert, C.,Mathieu, M. Structural basis for human monoglyceride lipase inhibition. J.Mol.Biol., 396:663-673, 2010 Cited by PubMed: 19962385 DOI: 10.1016/j.jmb.2009.11.060 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation