3JVF

Crystal structure of an Interleukin-17 receptor complex

Summary for 3JVF

• Entry DOI: 10.2210/pdb3jvf/pdb
• Descriptor: Interleukin-17F, Interleukin-17 receptor A, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: cytokine, interleukin, cysteine-knot growth factor, receptor-cytokine complex, disulfide bond, glycoprotein, secreted, membrane, receptor, transmembrane, signaling protein, signaling protein - cytokine complex, signaling protein / cytokine
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 64631.36

Authors

Ely, L.K.,Garcia, K.C. (deposition date: 2009-09-16, release date: 2009-10-20, Last modification date: 2020-07-29)

Primary citation

Ely, L.K.,Fischer, S.,Garcia, K.C.
Structural basis of receptor sharing by interleukin 17 cytokines.
Nat.Immunol., 10:1245-1251, 2009

PubMed Abstract: Interleukin 17 (IL-17)-producing helper T cells (T(H)-17 cells), together with their effector cytokines, including members of the IL-17 family, are emerging as key mediators of chronic inflammatory and autoimmune disorders. Here we present the crystal structure of a complex of IL-17 receptor A (IL-17RA) bound to IL-17F in a 1:2 stoichiometry. The mechanism of complex formation was unique for cytokines and involved the engagement of IL-17 by two fibronectin-type domains of IL-17RA in a groove between the IL-17 homodimer interface. Binding of the first receptor to the IL-17 cytokines modulated the affinity and specificity of the second receptor-binding event, thereby promoting heterodimeric versus homodimeric complex formation. IL-17RA used a common recognition strategy to bind to several members of the IL-17 family, which allows it to potentially act as a shared receptor in multiple different signaling complexes.

PubMed: 19838198
DOI: 10.1038/ni.1813

Experimental method

X-RAY DIFFRACTION (3.3 Å)