3JSW
Human PDE9 in complex with selective inhibitor
Summary for 3JSW
Entry DOI | 10.2210/pdb3jsw/pdb |
Related | 3JSI |
Descriptor | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | phosphodiesterase, cgmp, hydrolase, manganese, metal-binding, phosphoprotein |
Biological source | Homo sapiens (human) |
Cellular location | Isoform PDE9A1: Cell projection, ruffle membrane . Isoform PDE9A2: Cell projection, ruffle membrane . Isoform PDE9A3: Cytoplasm . Isoform PDE9A17: Cytoplasm : O76083 |
Total number of polymer chains | 2 |
Total formula weight | 78608.17 |
Authors | |
Primary citation | Verhoest, P.R.,Proulx-Lafrance, C.,Corman, M.,Chenard, L.,Helal, C.J.,Hou, X.,Kleiman, R.,Liu, S.,Marr, E.,Menniti, F.S.,Schmidt, C.J.,Vanase-Frawley, M.,Schmidt, A.W.,Williams, R.D.,Nelson, F.R.,Fonseca, K.R.,Liras, S. Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy. J.Med.Chem., 52:7946-7949, 2009 Cited by PubMed: 19919087DOI: 10.1021/jm9015334 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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