3JSW
Human PDE9 in complex with selective inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | polymer | 329 | 38862.9 | 2 | UniProt (O76083) Pfam (PF00233) | Homo sapiens (human) | |
| 2 | C, F (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, G (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E, H (A, B) | 6-[(3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl]-1-(1-methylethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one | non-polymer | 351.4 | 2 | Chemie (JAR) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 302 | Chemie (HOH) |
Sequence modifications
A, B: 182 - 506 (UniProt: O76083)
| PDB | External Database | Details |
|---|---|---|
| Gly 178 | - | expression tag |
| Ser 179 | - | expression tag |
| His 180 | - | expression tag |
| Met 181 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 77725.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 882.3 | |
| All* | Total formula weight | 78608.2 |
