3JSG

Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 707 at 1.58a resolution

3JSG の概要

• エントリーDOI: 10.2210/pdb3jsg/pdb
• 関連するPDBエントリー: 3JSF 3JTU
• 分子名称: Macrophage migration inhibitory factor, 7-(pyridin-3-ylmethyl)quinolin-8-ol, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: protein-ligand complex, cytokine, cytoplasm, immune response, inflammatory response, innate immunity, isomerase, phosphoprotein, secreted
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted : P14174
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 41275.62

構造登録者

Mclean, L.,Zhang, Y. (登録日: 2009-09-10, 公開日: 2009-11-10, 最終更新日: 2023-09-06)

• 主引用文献: McLean, L.R.,Zhang, Y.,Li, H.,Li, Z.,Lukasczyk, U.,Choi, Y.M.,Han, Z.,Prisco, J.,Fordham, J.,Tsay, J.T.,Reiling, S.,Vaz, R.J.,Li, Y.; Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening.; Bioorg.Med.Chem.Lett., 19:6717-6720, 2009; PubMed: 19836948; DOI: 10.1016/j.bmcl.2009.09.106

実験手法

X-RAY DIFFRACTION (1.58 Å)