3JPX

EED: A Novel Histone Trimethyllysine Binder Within The EED-EZH2 Polycomb Complex

3JPX の概要

• エントリーDOI: 10.2210/pdb3jpx/pdb
• 関連するPDBエントリー: 3JZG 3JZH
• 分子名称: Polycomb protein EED, HISTONE PEPTIDE (3 entities in total)
• 機能のキーワード: histone binding, structural genomics, sgc, structural genomics consortium, alternative initiation, chromatin regulator, nucleus, phosphoprotein, repressor, transcription, transcription regulation, wd repeat, gene regulation
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: O75530
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 47954.48

構造登録者

Xu, C.,Bian, C.B.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Min, J.,Structural Genomics Consortium (SGC) (登録日: 2009-09-04, 公開日: 2009-10-20, 最終更新日: 2023-09-06)

• 主引用文献: Xu, C.,Bian, C.,Yang, W.,Galka, M.,Ouyang, H.,Chen, C.,Qiu, W.,Liu, H.,Jones, A.E.,Mackenzie, F.,Pan, P.,Li, S.S.,Wang, H.,Min, J.; Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2).; Proc.Natl.Acad.Sci.USA, 107:19266-19271, 2010; PubMed: 20974918; DOI: 10.1073/pnas.1008937107

実験手法

X-RAY DIFFRACTION (2.05 Å)