3IXE

Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase

Summary for 3IXE

• Entry DOI: 10.2210/pdb3ixe/pdb
• Descriptor: Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 2, ZINC ION, ... (4 entities in total)
• Functional Keywords: ilk, integrin-linked kinase, pinch, lim, ankyrin repeat, ank, ipp, integrin-mediated signaling, ank repeat, lim domain, zinc, atp-binding, cell junction, cell membrane, kinase, membrane, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, alternative splicing, metal-binding, nucleus, signaling protein-signaling protein complex, signaling protein/signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cell junction, focal adhesion: Q13418; Nucleus (Potential): Q7Z4I7
• Total number of polymer chains: 2
• Total formula weight: 28865.16

Authors

Chiswell, B.P.,Stiegler, A.L.,Boggon, T.J.,Calderwood, D.A. (deposition date: 2009-09-03, release date: 2009-12-15, Last modification date: 2023-09-06)

• Primary citation: Chiswell, B.P.,Stiegler, A.L.,Razinia, Z.,Nalibotski, E.,Boggon, T.J.,Calderwood, D.A.; Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase.; J.Struct.Biol., 170:157-163, 2010; PubMed: 19963065; DOI: 10.1016/j.jsb.2009.12.002

Experimental method

X-RAY DIFFRACTION (1.9 Å)