3IWY

Crystal structure of human MDM2 complexed with D-peptide (12 residues)

Summary for 3IWY

Entry DOI	10.2210/pdb3iwy/pdb
Related	1YCR 3EQS 3IUX
Related PRD ID	PRD_001088
Descriptor	D-peptide inhibitor, E3 ubiquitin-protein ligase Mdm2 (3 entities in total)
Functional Keywords	mdm2, p53 binding domain, d-peptide activator of p53, host-virus interaction, ligase, metal-binding, nucleus, phosphoprotein, proto-oncogene, ubl conjugation pathway, zinc-finger, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Cellular location	Nucleus, nucleoplasm: Q00987
Total number of polymer chains	4
Total formula weight	23125.27
Authors	Pazgier, M.,Lu, W. (deposition date: 2009-09-03, release date: 2010-04-21, Last modification date: 2023-11-22)
Primary citation	Liu, M.,Li, C.,Pazgier, M.,Li, C.,Mao, Y.,Lv, Y.,Gu, B.,Wei, G.,Yuan, W.,Zhan, C.,Lu, W.Y.,Lu, W. D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms. Proc.Natl.Acad.Sci.USA, 398:200-213, 2010 Cited by PubMed: 20660730 DOI: 10.1073/pnas.1008930107 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.93 Å)

Structure validation