3IWY
Crystal structure of human MDM2 complexed with D-peptide (12 residues)
Summary for 3IWY
Entry DOI | 10.2210/pdb3iwy/pdb |
Related | 1YCR 3EQS 3IUX |
Related PRD ID | PRD_001088 |
Descriptor | D-peptide inhibitor, E3 ubiquitin-protein ligase Mdm2 (3 entities in total) |
Functional Keywords | mdm2, p53 binding domain, d-peptide activator of p53, host-virus interaction, ligase, metal-binding, nucleus, phosphoprotein, proto-oncogene, ubl conjugation pathway, zinc-finger, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Cellular location | Nucleus, nucleoplasm: Q00987 |
Total number of polymer chains | 4 |
Total formula weight | 23125.27 |
Authors | Pazgier, M.,Lu, W. (deposition date: 2009-09-03, release date: 2010-04-21, Last modification date: 2023-11-22) |
Primary citation | Liu, M.,Li, C.,Pazgier, M.,Li, C.,Mao, Y.,Lv, Y.,Gu, B.,Wei, G.,Yuan, W.,Zhan, C.,Lu, W.Y.,Lu, W. D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms. Proc.Natl.Acad.Sci.USA, 398:200-213, 2010 Cited by PubMed: 20660730DOI: 10.1073/pnas.1008930107 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
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