3IWM

The octameric SARS-CoV main protease

Summary for 3IWM

• Entry DOI: 10.2210/pdb3iwm/pdb
• Related PRD ID: PRD_002214
• Descriptor: 3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE (2 entities in total)
• Functional Keywords: sars-cov, main protease, octamer, active conformation, hydrolase
• Biological source: SARS coronavirus (SARS-CoV); More
• Cellular location: Non-structural protein 3: Host membrane ; Multi-pass membrane protein . Non-structural protein 4: Host membrane ; Multi-pass membrane protein . Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region : P0C6U8
• Total number of polymer chains: 8
• Total formula weight: 138229.71

Authors

Zhong, N.,Zhang, S.,Xue, F.,Lou, Z.,Rao, Z.,Xia, B. (deposition date: 2009-09-02, release date: 2010-07-21, Last modification date: 2023-11-15)

• Primary citation: Zhang, S.,Zhong, N.,Xue, F.,Kang, X.,Ren, X.,Chen, J.,Jin, C.,Lou, Z.,Xia, B.; Three-dimensional domain swapping as a mechanism to lock the active conformation in a super-active octamer of SARS-CoV main protease; Protein Cell, 1:371-383, 2010; PubMed: 21203949; DOI: 10.1007/s13238-010-0044-8

Experimental method

X-RAY DIFFRACTION (3.2 Å)