3IWM

The octameric SARS-CoV main protease

Summary for 3IWM

Related PRD IDPRD_002214
Descriptor3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE (2 entities in total)
Functional Keywordssars-cov, main protease, octamer, active conformation, hydrolase
Biological sourceSARS coronavirus (SARS-CoV)
More
Cellular locationNon-structural protein 3: Host membrane ; Multi-pass membrane protein . Non-structural protein 4: Host membrane ; Multi-pass membrane protein . Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region  P0C6U8
Total number of polymer chains8
Total molecular weight138229.71
Authors
Zhong, N.,Zhang, S.,Xue, F.,Lou, Z.,Rao, Z.,Xia, B. (deposition date: 2009-09-02, release date: 2010-07-21, Last modification date: 2012-03-28)
Primary citation
Zhang, S.,Zhong, N.,Xue, F.,Kang, X.,Ren, X.,Chen, J.,Jin, C.,Lou, Z.,Xia, B.
Three-dimensional domain swapping as a mechanism to lock the active conformation in a super-active octamer of SARS-CoV main protease
Protein Cell, 1:371-383, 2010
PubMed: 21203949 (PDB entries with the same primary citation)
DOI: 10.1007/s13238-010-0044-8
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.2 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.265489.0%20.7%3.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution