3IWM

The octameric SARS-CoV main protease

3IWM の概要

• エントリーDOI: 10.2210/pdb3iwm/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002214
• 分子名称: 3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE (2 entities in total)
• 機能のキーワード: sars-cov, main protease, octamer, active conformation, hydrolase
• 由来する生物種: SARS coronavirus (SARS-CoV); 詳細
• 細胞内の位置: Non-structural protein 3: Host membrane ; Multi-pass membrane protein . Non-structural protein 4: Host membrane ; Multi-pass membrane protein . Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region : P0C6U8
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 138229.71

構造登録者

Zhong, N.,Zhang, S.,Xue, F.,Lou, Z.,Rao, Z.,Xia, B. (登録日: 2009-09-02, 公開日: 2010-07-21, 最終更新日: 2023-11-15)

• 主引用文献: Zhang, S.,Zhong, N.,Xue, F.,Kang, X.,Ren, X.,Chen, J.,Jin, C.,Lou, Z.,Xia, B.; Three-dimensional domain swapping as a mechanism to lock the active conformation in a super-active octamer of SARS-CoV main protease; Protein Cell, 1:371-383, 2010; PubMed: 21203949; DOI: 10.1007/s13238-010-0044-8

実験手法

X-RAY DIFFRACTION (3.2 Å)