3IWM
The octameric SARS-CoV main protease
3IWM の概要
エントリーDOI | 10.2210/pdb3iwm/pdb |
関連するBIRD辞書のPRD_ID | PRD_002214 |
分子名称 | 3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE (2 entities in total) |
機能のキーワード | sars-cov, main protease, octamer, active conformation, hydrolase |
由来する生物種 | SARS coronavirus (SARS-CoV) 詳細 |
細胞内の位置 | Non-structural protein 3: Host membrane ; Multi-pass membrane protein . Non-structural protein 4: Host membrane ; Multi-pass membrane protein . Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region : P0C6U8 |
タンパク質・核酸の鎖数 | 8 |
化学式量合計 | 138229.71 |
構造登録者 | |
主引用文献 | Zhang, S.,Zhong, N.,Xue, F.,Kang, X.,Ren, X.,Chen, J.,Jin, C.,Lou, Z.,Xia, B. Three-dimensional domain swapping as a mechanism to lock the active conformation in a super-active octamer of SARS-CoV main protease Protein Cell, 1:371-383, 2010 Cited by PubMed: 21203949DOI: 10.1007/s13238-010-0044-8 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.2 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード