3IW2

Crystal structure of Mycobacterium tuberculosis cytochrome P450 CYP125 in complex with econazole

3IW2 の概要

• エントリーDOI: 10.2210/pdb3iw2/pdb
• 関連するPDBエントリー: 2IW1 3IVY 3IW0
• 分子名称: Cytochrome P450 CYP125, 4-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, PROTOPORPHYRIN IX CONTAINING FE, ... (4 entities in total)
• 機能のキーワード: econazole, cytochrome p450, tuberculosis, monooxygenase, cholesterol, heme, iron, metal-binding, oxidoreductase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 49489.66

構造登録者

McLean, K.J.,Levy, C.,Munro, A.W.,Leys, D. (登録日: 2009-09-02, 公開日: 2009-11-03, 最終更新日: 2023-09-06)

• 主引用文献: McLean, K.J.,Lafite, P.,Levy, C.,Cheesman, M.R.,Mast, N.,Pikuleva, I.A.,Leys, D.,Munro, A.W.; The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection.; J.Biol.Chem., 284:35524-35533, 2009; PubMed: 19846552; DOI: 10.1074/jbc.M109.032706

実験手法

X-RAY DIFFRACTION (2.19 Å)