3IU3

Crystal structure of the Fab fragment of therapeutic antibody Basiliximab in complex with IL-2Ra (CD25) ectodomain

3IU3 の概要

分子名称Heavy chain of Fab fragment of Basiliximab, Light chain of Fab fragment of Basiliximab, Interleukin-2 receptor alpha chain, ... (5 entities in total)
機能のキーワードil-2ra, cd25, basiliximab, simulect, therapeutic antibody, disulfide bond, glycoprotein, membrane, receptor, sushi, transmembrane, immune system
由来する生物種Mus musculus, Homo sapiens (mouse, human)
詳細
細胞内の位置Membrane; Single-pass type I membrane protein P01589
ポリマー鎖数9
分子量合計216114.25
構造登録者
Du, J.,Yang, H.,Wang, J.,Ding, J. (登録日: 2009-08-29, 公開日: 2010-01-26, 最終更新日: 2014-02-05)
主引用文献
Du, J.,Yang, H.,Zhang, D.,Wang, J.,Guo, H.,Peng, B.,Guo, Y.,Ding, J.
Structural basis for the blockage of IL-2 signaling by therapeutic antibody basiliximab
J.Immunol., 184:1361-1368, 2010
PubMed: 20032294 (主引用文献が同じPDBエントリー)
DOI: 10.4049/jimmunol.0903178
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.9 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.20881.4%5.1%5.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード