3IU3

Crystal structure of the Fab fragment of therapeutic antibody Basiliximab in complex with IL-2Ra (CD25) ectodomain

3IU3 の概要

• エントリーDOI: 10.2210/pdb3iu3/pdb
• 分子名称: Heavy chain of Fab fragment of Basiliximab, Light chain of Fab fragment of Basiliximab, Interleukin-2 receptor alpha chain, ... (4 entities in total)
• 機能のキーワード: il-2ra, cd25, basiliximab, simulect, therapeutic antibody, disulfide bond, glycoprotein, membrane, receptor, sushi, transmembrane, immune system
• 由来する生物種: Mus musculus, Homo sapiens (mouse, human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01589
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 216006.16

構造登録者

Du, J.,Yang, H.,Wang, J.,Ding, J. (登録日: 2009-08-29, 公開日: 2010-01-26, 最終更新日: 2023-11-01)

• 主引用文献: Du, J.,Yang, H.,Zhang, D.,Wang, J.,Guo, H.,Peng, B.,Guo, Y.,Ding, J.; Structural basis for the blockage of IL-2 signaling by therapeutic antibody basiliximab; J.Immunol., 184:1361-1368, 2010; PubMed: 20032294; DOI: 10.4049/jimmunol.0903178

実験手法

X-RAY DIFFRACTION (2.9 Å)