3ITZ

Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridazine Inhibitor

3ITZ の概要

• エントリーDOI: 10.2210/pdb3itz/pdb
• 関連するPDBエントリー: 1YQJ 3DS6 3DT1 3GFE
• 分子名称: Mitogen-activated protein kinase 14, 4-chloro-N-cyclopropyl-3-{[1-(2,6-difluorophenyl)-1H-pyrazolo[3,4-d]pyridazin-4-yl]amino}benzamide (3 entities in total)
• 機能のキーワード: serine/threonine-protein kinase, transferase, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm (By similarity): Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42439.77

構造登録者

Mohr, C.,Jordan, S. (登録日: 2009-08-28, 公開日: 2010-03-02, 最終更新日: 2024-02-21)

• 主引用文献: Wurz, R.P.,Pettus, L.H.,Henkle, B.,Sherman, L.,Plant, M.,Miner, K.,McBride, H.J.,Wong, L.M.,Saris, C.J.,Lee, M.R.,Chmait, S.,Mohr, C.,Hsieh, F.,Tasker, A.S.; Part 2: Structure-activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase.; Bioorg.Med.Chem.Lett., 20:1680-1684, 2010; PubMed: 20138761; DOI: 10.1016/j.bmcl.2010.01.059

実験手法

X-RAY DIFFRACTION (2.25 Å)