3ITN
Crystal structure of Pseudo-activated Procaspase-3
Summary for 3ITN
Entry DOI | 10.2210/pdb3itn/pdb |
Related PRD ID | PRD_000238 |
Descriptor | Caspase-3, ACETYL-ASP-GLU-VAL-ASP-CHLOROMETHYL KETONE inhibitor (3 entities in total) |
Functional Keywords | caspase-3, apoptosis, hydrolase, phosphoprotein, protease, s-nitrosylation, thiol protease, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P42574 |
Total number of polymer chains | 2 |
Total formula weight | 29168.53 |
Authors | Walters, J.,Pop, C.,Scott, F.L.,Drag, M.,Swartz, P.D.,Mattos, C.,Salvesen, G.S.,Clark, A.C. (deposition date: 2009-08-28, release date: 2010-03-02, Last modification date: 2023-09-06) |
Primary citation | Walters, J.,Pop, C.,Scott, F.L.,Drag, M.,Swartz, P.,Mattos, C.,Salvesen, G.S.,Clark, A.C. A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis. Biochem.J., 424:335-345, 2009 Cited by PubMed: 19788411DOI: 10.1042/BJ20090825 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.63 Å) |
Structure validation
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